Details

Autor(en) / Beteiligte

• Liu, Xue
• Wang, Qi
• Zhang, Bao
• Jiang, Tao
• Zeng, Wenbing

Titel

Diagnostic accuracy of 18 F-PSMA-1007 PET/CT for prostate cancer in primary staging and biochemical recurrence with different serum PSA levels: A systematic review and meta-analysis

Ist Teil von

• Hellenic journal of nuclear medicine, 2022-01, Vol.25 (1), p.88

Ort / Verlag

Greece

Erscheinungsjahr

2022

Quelle

MEDLINE

Beschreibungen/Notizen

• We performed a systematic review and meta-analysis to evaluate the application value of fluorine-18-prostate specific membrane antigen ( F-PSMA-1007) positron emission tomography/computed tomography (PET/CT) in patients with different serum prostate specific antigen (PSA) levels and primary prostate cancer (PCa) or the biochemical recurrence of PCa. A comprehensive electronic literature search of the PubMed, Embase and Cochrane Library databases was conducted in accordance with the PRISMA statement. We calculated the pooled sensitivity and specificity of F-PSMA-1007 PET/CT in PCa. A summary receiver operator characteristic (SROC) curve and the area under the curve (AUC) were used to assess the accuracy of F-PSMA-1007 PET/CT for PCa. The final analysis included 11 studies that described 799 patients and 4261 lesions with F-PSMA-1007 PET/CT in PCa. The pooled sensitivity and specificity of F-PSMA-1007 PET/CT in PCa were 0.836 and 0.946, respectively. The per-patient pooled sensitivity and specificity of F-PSMA-1007 PET/CT in PCa were 0.934 and 0.453, and the per-lesion values were 0.816 and 0.979, respectively. The pooled sensitivity and specificity of F-PSMA-1007 PET/CT in PCa with PSA>2ng/mL were 0.923 and 0.442 in a patient-based analysis and 0.799 and 0.961 in a lesion-based analysis, respectively. The pooled sensitivity and specificity of F-PSMA-1007 PET/CT in PCa with PSA≤2ng/mL were 0.832 and 0.277 in a patient-based analysis, respectively. This meta-analysis showed that F-PSMA-1007 PET/CT has a higher diagnostic value for prostate cancer in the setting of primary PCa and biochemical recurrence. As serum PSA levels increase, the diagnostic accuracy of F-PSMA-1007 PET/CT also improves.