Details

Autor(en) / Beteiligte

• Wanner, Nicola
• Andrieux, Geoffroy
• Badia-I-Mompel, Pau
• Edler, Carolin
• Pfefferle, Susanne
• Lindenmeyer, Maja T
• Schmidt-Lauber, Christian
• Czogalla, Jan
• Wong, Milagros N
• Okabayashi, Yusuke
• Braun, Fabian
• Lütgehetmann, Marc
• Meister, Elisabeth
• Lu, Shun
• Noriega, Maria L M
• Günther, Thomas
• Grundhoff, Adam
• Fischer, Nicole
• Bräuninger, Hanna
• Lindner, Diana
• Westermann, Dirk
• Haas, Fabian
• Roedl, Kevin
• Kluge, Stefan
• Addo, Marylyn M
• Huber, Samuel
• Lohse, Ansgar W
• Reiser, Jochen
• Ondruschka, Benjamin
• Sperhake, Jan P
• Saez-Rodriguez, Julio
• Boerries, Melanie
• Hayek, Salim S
• Aepfelbacher, Martin
• Scaturro, Pietro
• Puelles, Victor G
• Huber, Tobias B

Titel

Molecular consequences of SARS-CoV-2 liver tropism

Ist Teil von

• Nature metabolism, 2022-03, Vol.4 (3), p.310-319

Ort / Verlag

Germany

Erscheinungsjahr

2022

Quelle

MEDLINE

Beschreibungen/Notizen

• Extrapulmonary manifestations of COVID-19 have gained attention due to their links to clinical outcomes and their potential long-term sequelae . Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) displays tropism towards several organs, including the heart and kidney. Whether it also directly affects the liver has been debated . Here we provide clinical, histopathological, molecular and bioinformatic evidence for the hepatic tropism of SARS-CoV-2. We find that liver injury, indicated by a high frequency of abnormal liver function tests, is a common clinical feature of COVID-19 in two independent cohorts of patients with COVID-19 requiring hospitalization. Using autopsy samples obtained from a third patient cohort, we provide multiple levels of evidence for SARS-CoV-2 liver tropism, including viral RNA detection in 69% of autopsy liver specimens, and successful isolation of infectious SARS-CoV-2 from liver tissue postmortem. Furthermore, we identify transcription-, proteomic- and transcription factor-based activity profiles in hepatic autopsy samples, revealing similarities to the signatures associated with multiple other viral infections of the human liver. Together, we provide a comprehensive multimodal analysis of SARS-CoV-2 liver tropism, which increases our understanding of the molecular consequences of severe COVID-19 and could be useful for the identification of organ-specific pharmacological targets.