Details

Autor(en) / Beteiligte

• Bannoud, Nadia
• García, P Alfredo
• Gambarte-Tudela, Julian
• Sundblad, Victoria
• Cagnoni, Alejandro J
• Bach, Camila A
• Pérez Saez, Juan M
• Blidner, Ada G
• Maller, Sebastián M
• Mariño, Karina V
• Salatino, Mariana
• Cerliani, Juan P
• Rabinovich, Gabriel A
• Croci, Diego O

Titel

Untangling Galectin-Mediated Circuits that Control Hypoxia-Driven Angiogenesis

Ist Teil von

• Methods in molecular biology (Clifton, N.J.), 2022, Vol.2442, p.635

Ort / Verlag

United States

Erscheinungsjahr

2022

Quelle

MEDLINE

Beschreibungen/Notizen

• Development of an aberrant vascular network is a hallmark of the multistep pathological process of tumor growth and metastasis. In response to hypoxia, several pro-angiogenic factors are synthesized to support vascularization programs required for cancer progression. Emerging data indicate the involvement of glycans and glycan-binding proteins as critical regulators of vascular circuits in health and disease. Galectins may be regulated by hypoxic conditions and control angiogenesis in different physiopathological settings. These β-galactoside-binding proteins may promote sprouting angiogenesis by interacting with different glycosylated receptors and triggering distinct signaling pathways. Understanding the role of galectins in tumor neovascularization will contribute to the design of novel anti-angiogenic therapies aimed at complementing current anti-cancer modalities and overcoming resistance to these treatments. Here we describe selected strategies and methods used to study the role of hypoxia-regulated galectins in the regulation of blood vessel formation.