Details

Autor(en) / Beteiligte

• Ulrich, Benjamin J
• Kharwadkar, Rakshin
• Chu, Michelle
• Pajulas, Abigail
• Muralidharan, Charanya
• Koh, Byunghee
• Fu, Yongyao
• Gao, Hongyu
• Hayes, Tristan A
• Zhou, Hong-Ming
• Goplen, Nick P
• Nelson, Andrew S
• Liu, Yunlong
• Linnemann, Amelia K
• Turner, Matthew J
• Licona-Limón, Paula
• Flavell, Richard A
• Sun, Jie
• Kaplan, Mark H

Titel

Allergic airway recall responses require IL-9 from resident memory CD4 + T cells

Ist Teil von

• Science immunology, 2022-03, Vol.7 (69), p.eabg9296

Ort / Verlag

United States

Erscheinungsjahr

2022

Quelle

MEDLINE

Beschreibungen/Notizen

• Asthma is a chronic inflammatory lung disease with intermittent flares predominately mediated through memory T cells. Yet, the identity of long-term memory cells that mediate allergic recall responses is not well defined. In this report, using a mouse model of chronic allergen exposure followed by an allergen-free rest period, we characterized a subpopulation of CD4 T cells that secreted IL-9 as an obligate effector cytokine. IL-9-secreting cells had a resident memory T cell phenotype, and blocking IL-9 during a recall challenge or deleting IL-9 from T cells significantly diminished airway inflammation and airway hyperreactivity. T cells secreted IL-9 in an allergen recall-specific manner, and secretion was amplified by IL-33. Using scRNA-seq and scATAC-seq, we defined the cellular identity of a distinct population of T cells with a proallergic cytokine pattern. Thus, in a recall model of allergic airway inflammation, IL-9 secretion from a multicytokine-producing CD4 T cell population was required for an allergen recall response.