Details

Autor(en) / Beteiligte

• Ünlü, Begüm
• Türsen, Ümit
• Jabalameli, Navid
• Abdollahimajd, Fahimeh
• Rajabi, Fateme
• Rezaei, Nima

Titel

Immunogenetics of Lupus Erythematosus

Ist Teil von

• Advances in experimental medicine and biology, 2022, Vol.1367, p.213-257

Ort / Verlag

Switzerland: Springer International Publishing AG

Erscheinungsjahr

2022

Quelle

MEDLINE

Beschreibungen/Notizen

• Lupus erythematosus (LE) is a heterogeneous disease with a wide range of manifestations ranging from localized lesions in cutaneous lupusCutaneous lupus erythematosus (CLE) to severe disseminated disease in systemic lupus erythematosus (SLE). LupusLupus results from a complex interaction between genetic and epigenetic backgrounds and environmental triggers that cause loss of tolerance to self-antigens and the formation of autoantibodies. Genetic susceptibility plays a key role in the pathogenesisPathogenesis of lupus erythematosus. In most cases, multiple common alleles with modest effect sizes are combined to result in the polygenic inheritance of the disease but monogenic variants of lupusLupus have also been described. Genes from the innate and adaptive immune system along with genes involved in apoptosis and immunoglobulin clearance have been linked to SLE. This chapter aims to explore the functions of these genes and their contribution to the pathogenesisPathogenesis of the disease.