Details

Autor(en) / Beteiligte

• DeFreitas, Marissa J
• Griffin, Russell
• Sanderson, Keia
• Nada, Arwa
• Charlton, Jennifer R
• Jetton, Jennifer G
• Kent, Alison L
• Guillet, Ronnie
• Askenazi, David
• Abitbol, Carolyn L

Titel

Maternal Hypertension Disorders and Neonatal Acute Kidney Injury: Results from the AWAKEN Study

Ist Teil von

• American journal of perinatology, 2024-04, Vol.41 (5), p.649

Ort / Verlag

United States

Erscheinungsjahr

2024

Quelle

MEDLINE

Beschreibungen/Notizen

• This study aimed to examine the association between maternal hypertension (HTN) exposure and neonatal acute kidney injury (AKI).  Retrospective cohort study of 2,162 neonates admitted to 24 neonatal intensive care units (NICUs). Neonates were classified into the following exposure groups: any maternal HTN, chronic maternal HTN, preeclampsia/eclampsia, both, or neither. Demographics, clinical characteristics, and AKI status were compared using Chi-square and analysis of variance. General estimating logistic regression was used to estimate adjusted odds ratios and included a stratified analysis for site of delivery.  Neonates exposed to any maternal HTN disorder had a tendency toward less overall and early AKI. When stratified by inborn versus outborn, exposure to both maternal HTN disorders was associated with a significantly reduced odds of early AKI only in the inborn neonates.  Exposure to maternal HTN, especially preeclampsia/eclampsia superimposed on chronic HTN, was associated with less likelihood of early AKI in the inborn group. · Maternal HTN is associated with less neonatal AKI.. · Maternal HTN category is variably associated with AKI.. · Inborn status is an important contributor to this association..