Details

Autor(en) / Beteiligte

• Chikatani, Kenichi
• Sato, Taku
• Ito, Tetsuya
• Chika, Noriyasu
• Toyomasu, Yoshitaka
• Mori, Yoshiko
• Suzuki, Okihide
• Hatano, Satoshi
• Ishiguro, Toru
• Matsuyama, Takatoshi
• Kumagai, Yoichi
• Ishibashi, Keiichiro
• Mochiki, Erito
• Ishida, Hideyuki
• Oya, Hiroyuki

Titel

Changes in Renal Function and Feasibility of Adjuvant Chemotherapy for Colorectal Cancer Patients with Diverting Ileostomy after Ileal Pouch-Anal Anastomosis

Ist Teil von

• Gan to kagaku ryoho, 2021-12, Vol.48 (13), p.1925

Ort / Verlag

Japan

Erscheinungsjahr

2021

Quelle

MEDLINE

Beschreibungen/Notizen

• We investigated changes in estimated glomerular filtration rate(eGFR)in 11 colorectal cancer patients(6 familial adenomatous polyposis, 5 ulcerative colitis)who underwent restorative proctocolectomy with ileal pouch-anal anastomosis(IPAA) and diverting ileostomy(DI), the tolerability and adverse events of adjuvant chemotherapy(ACT)in 4 cases. After IPAA, eGFR decreased significantly(p=0.02)and did not return to the preoperative level even after stoma closure(p<0.01). mFOLFOX6 was selected as the regimen in 4 candidates, and no significant changes in eGFR after ACT were observed. The relative dose intensity of oxaliplatin was 91.7%, and no gastrointestinal adverse events of Grade 3 or higher were observed. Although in a small number of cases, mFOLFOX6 as ACT after IPAA and DI may be feasible.