Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...

Details

Autor(en) / Beteiligte
Titel
Chaperone mediated autophagy contributes to the newly synthesized histones H3 and H4 quality control
Ist Teil von
  • Nucleic acids research, 2022-02, Vol.50 (4), p.1875-1887
Ort / Verlag
England
Erscheinungsjahr
2022
Quelle
MEDLINE
Beschreibungen/Notizen
  • Although there are several pathways to ensure that proteins are folded properly in the cell, little is known about the molecular mechanisms regulating histone folding and proteostasis. In this work, we identified that chaperone-mediated autophagy (CMA) is the main pathway involved in the degradation of newly synthesized histones H3 and H4. This degradation is finely regulated by the interplay between HSC70 and tNASP, two histone interacting proteins. tNASP stabilizes histone H3 levels by blocking the direct transport of histone H3 into lysosomes. We further demonstrate that CMA degrades unfolded histone H3. Thus, we reveal that CMA is the main degradation pathway involved in the quality control of histone biogenesis, evidencing an additional mechanism in the intricate network of histone cellular proteostasis.
Sprache
Englisch
Identifikatoren
ISSN: 0305-1048
eISSN: 1362-4962
DOI: 10.1093/nar/gkab1296
Titel-ID: cdi_pubmed_primary_35037039

Weiterführende Literatur

Empfehlungen zum selben Thema automatisch vorgeschlagen von bX