Details

Autor(en) / Beteiligte

• Tomofuji, Yoshihiko
• Kishikawa, Toshihiro
• Maeda, Yuichi
• Ogawa, Kotaro
• Nii, Takuro
• Okuno, Tatsusada
• Oguro-Igashira, Eri
• Kinoshita, Makoto
• Yamamoto, Kenichi
• Sonehara, Kyuto
• Yagita, Mayu
• Hosokawa, Akiko
• Motooka, Daisuke
• Matsumoto, Yuki
• Matsuoka, Hidetoshi
• Yoshimura, Maiko
• Ohshima, Shiro
• Nakamura, Shota
• Inohara, Hidenori
• Mochizuki, Hideki
• Takeda, Kiyoshi
• Kumanogoh, Atsushi
• Okada, Yukinori

Titel

Whole gut virome analysis of 476 Japanese revealed a link between phage and autoimmune disease

Ist Teil von

• Annals of the rheumatic diseases, 2022-02, Vol.81 (2), p.278

Ort / Verlag

England

Erscheinungsjahr

2022

Quelle

MEDLINE

Beschreibungen/Notizen

• The relationship between autoimmune diseases and the gut microbiome has been intensively studied, and several autoimmunity-associated bacterial taxa have been identified. However, much less is known about the roles of the gut virome in autoimmune diseases. Here, we performed a whole gut virome analysis based on the shotgun sequencing of 476 Japanese which included patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), multiple sclerosis and healthy control subjects. Our case-control comparison of the viral abundance revealed that crAss-like phages, which are one of the main components of a healthy gut virome, significantly decreased in the gut of the patients with autoimmune disease, specifically the patients with RA and SLE. In addition, significantly decreased in the gut of the patients with SLE. To understand how these viruses affected the bacteriome, we performed a quantitative virus-bacterium association analysis and clustered regularly interspaced short palindromic repeat-based virus-bacterium interaction analysis. We identified a symbiosis between e and . In addition, multiple bacterial targets of crAss-like phages were identified (eg, spp). Our data suggest that the gut virome can affect our body either directly or via bacteria. Our analyses have elucidated a previously missing part of the autoimmunity-associated gut microbiome and presented new candidates that contribute to the development of autoimmune diseases.