Details

Autor(en) / Beteiligte

• Hassani, Seyedeh Faezeh
• Sayaf, Masoud
• Danandeh, Seyedeh Sara
• Nourollahzadeh, Zahra
• Shahmohammadi, Mahshid
• Akbari, Sanaz
• Shirvaliloo, Milad
• Sheervalilou, Roghayeh
• Shams, Zinat

Titel

Novel Insight Into the Association Between Obesity and Hepatocellular Carcinoma Occurrence and Recurrence: High-Throughput Microarray Data Set Analysis of Differentially Expressed Genes

Ist Teil von

• JCO clinical cancer informatics, 2021-12, Vol.5 (5), p.1169-1180

Ort / Verlag

United States

Erscheinungsjahr

2021

Quelle

MEDLINE

Beschreibungen/Notizen

• This study aims to identify potential biomarkers of hepatocellular carcinoma (HCC) occurrence/recurrence and obesity, along with the molecular mechanisms that involve these biomarkers. Three microarray data sets, namely GSE18897, GSE25097, and GSE36376 (genetic suppressor elements associated with obesity, tumor, and recurrence, respectively), were downloaded from Gene Expression Omnibus database to be investigated for their expression as differentially expressed genes (DEGs) in HCC and obesity. The functional and pathway enrichment analysis of these DEGs were identified by the Database for Annotation Visualization and Integrated Discovery. The protein-protein interaction network analysis was performed with STRING online tool and Cytoscape software. One hundred sixty common DEGs were screened. We found that these genes were associated with certain pathways such as metabolic pathways, terpenoid backbone biosynthesis, and adipocytokine signaling pathway. The involvements of 10 genes, including , , , , , , , , , and were identified in the subnetwork. and in the GSE18897 data set, , , , , , , , and in the GSE25097 data set, and , , , , , , , , and in the GSE36376 data set exhibited positive fold changes. These DEGs and pathways could be of diagnostic value as potential biomarkers involved in the pathogenesis of HCC, pertaining to both obesity and HCC occurrence/recurrence.