Details

Autor(en) / Beteiligte

• Guo, Y S
• Wu, Y D
• Ma, H
• Qi, L
• Zhang, S D
• Zang, Y J

Titel

The expression of GGCT in the bladder urothelial cell carcinoma and its clinical significance

Ist Teil von

• Zhōnghuá zhŏngliú zázhì, 2021-11, Vol.43 (11), p.1183

Ort / Verlag

China

Erscheinungsjahr

2021

Quelle

MEDLINE

Beschreibungen/Notizen

• To evaluate the expression and clinical significance of γ-glutamylcyclotransferase (GGCT) in patients with bladder urothelial cell carcinoma. Immunohistochemical staining for GGCT were performed on tissue sections of 86 patients with bladder urothelial cell carcinoma and 10 normal controls, and the correlations between GGCT and clinicopathological characteristics and the prognosis were analyzed. The positive rate of the expression of GGCT in 86 cases of bladder urothelial cell carcinoma was 61.6% (53/86). GGCT protein was located mainly in cancer cell cytoplasm, and it can be seen in the nucleus of the tumor cells in some cases. The level of GGCT expression was positively related to pathological classification ( <0.001), stage ( =0.020), and tumor size ( =0.025). Immunohistochemical semiquantitative analysis showed that the expression of GGCT in patients with T1 stage of non-muscle invasion bladder urothelial cell carcinoma was significantly higher than that with Ta stage ( =0.034). Kaplan-Meier analysis show