Details

Autor(en) / Beteiligte

• Max, Jeffrey E
• Judd, Nicholas
• Bigler, Erin D
• Wilde, Elisabeth A
• Patterson, Jo Ellen
• Edwards, Todd M
• Calahorra, Ainara
• De La Garza, Bianca G
• Vaida, Florin

Titel

Three-Month Psychiatric Outcome of Pediatric Mild Traumatic Brain Injury: A Controlled Study

Ist Teil von

• Journal of neurotrauma, 2021-12, Vol.38 (23), p.3341-3351

Ort / Verlag

United States

Erscheinungsjahr

2021

Quelle

MEDLINE

Beschreibungen/Notizen

• The objective was to clarify occurrence, phenomenology, and risk factors for novel psychiatric disorder (NPD) in the first 3 months after mild traumatic brain injury (mTBI) and orthopedic injury (OI). Children aged 8-15 years with mTBI (  = 220) and with OI but no TBI (  = 110) from consecutive admissions to an emergency department were followed prospectively at baseline and 3 months post-injury with semi-structured psychiatric interviews to document the number of NPDs that developed in each participant. Pre-injury child variables (adaptive, cognitive, and academic function, and psychiatric disorder), pre-injury family variables (socioeconomic status, family psychiatric history, and family function), and injury severity were assessed and analyzed as potential confounders and predictors of NPD. NPD occurred at a significantly higher frequency in children with mTBI versus OI in analyses unadjusted (mean ratio [MR] 3.647, 95% confidence interval [CI ] (1.264, 15.405),  = 0.014) and adjusted (MR = 3.724, CI (1.264, 15.945),  = 0.015) for potential confounders. In multi-predictor analyses, the factors besides mTBI that were significantly associated with higher NPD frequency after adjustment for each other were pre-injury lifetime psychiatric disorder [MR = 2.284, CI (1.026, 5.305),  = 0.043]; high versus low family psychiatric history [MR = 2.748, CI (1.201, 6.839),  = 0.016], and worse socio-economic status [MR = 0.618 per additional unit, CI (0.383, 0.973),  = 0.037]. These findings demonstrate that mild injury to the brain compared with an OI had a significantly greater deleterious effect on psychiatric outcome in the first 3 months post-injury. This effect was present even after accounting for specific child and family variables, which were themselves independently related to the adverse psychiatric outcome.