Details

Autor(en) / Beteiligte

• Cheo, S W
• Abdul Rashid, W N F A
• Ho, C V
• Ahmad Akhbar, R Z
• Low, Q J
• Rajahram, G S

Titel

Haemophagocytic lymphohistiocytosis secondary to dengue fever: a case report

Ist Teil von

• Hong Kong Medical Journal, 2021-08, Vol.27 (4), p.287-289

Ort / Verlag

China: Hong Kong Academy of Medicine

Erscheinungsjahr

2021

Quelle

MEDLINE

Beschreibungen/Notizen

• Upon arrival, he was alert with normal Glasgow Coma Scale score, blood pressure 126/82 mm Hg, pulse rate 126 beats per minute and temperature 37.7°C. Examination revealed jaundiced, cold peripheries, poor pulse volume, and a capillary refill time [greater than]2 s. Respiratory examination showed crepitations over the lung bases bilaterally. The diagnosis of HLH can be established in the presence of a molecular diagnosis consistent with HLH or the presence of five out of eight criteria: fever [greater than]38.5°C; splenomegaly; peripheral blood cytopenias; hypertriglyceridaemia; hypofibrinogenaemia; haemophagocytosis in bone marrow, spleen or liver; hyperferritinaemia ([greater than]500 ng/mL); and increased CD25/interleukin-2 receptor or reduced natural killer cell function.4The hallmark of diagnosis is observation of haemophagocytosis in the tissue. Pathophysiologically, viral infection of T cells leads to overproduction of cytokines such as tumour necrosis factor alpha and interferon gamma and can lead to uncontrolled histiocytic activity.