Zhongguo shi yan xue ye xue za zhi, 2021-08, Vol.29 (4), p.1011
2021
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- Autor(en) / Beteiligte
- Titel
- Clinical Significance of Truncated Mutant ΔJBP of TET2 Gene in Patients with Acute Myeloid Leukemia
- Ist Teil von
- Zhongguo shi yan xue ye xue za zhi, 2021-08, Vol.29 (4), p.1011
- Ort / Verlag
- China
- Erscheinungsjahr
- 2021
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- To the clinical characteristics and prognostic value of the patients with complete deletion of TET_JBP domain (ΔJBP) in TET2 acute myeloid leukemia (AML). Next Generation Sequencing technology was used to determine the mutations of 34 AML-related genes (including TET2 gene). The I-TASSER tool was used to predict the tertiary structure of the full-length TET2 protein and TET_JBP structure deletion. Among 38 AML patients with TET2 mutations, 22(57.9%) showed truncation mutations, of which 16 (72.7%) produced TET2ΔJBP truncation mutants. Protein structure prediction showed that the deletion of TET_JBP domain lead to the significant changes of tertiary structure in TET2 protein. Compared with the patients in non-ΔJBP group, the age of patients in ΔJBP group were older (63 vs 54 years old, P=0.047), and the occurrence rate of CEBPA double mutation (CEBPA ) were more frequency (31.3% vs 0, P=0.009), the complete remission (CR) rate after induction chemotherapy(37.5% vs 81.8%, P=0.008) were lower, the median EFS (5
- Sprache
- Chinesisch
- Identifikatoren
- ISSN: 1009-2137DOI: 10.19746/j.cnki.issn.1009-2137.2021.04.001Titel-ID: cdi_pubmed_primary_34362476