Pyridoxal kinase and poly(ADP-ribose) affect the immune microenvironment of locally advanced cancers
2021
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- Autor(en) / Beteiligte
- Titel
- Pyridoxal kinase and poly(ADP-ribose) affect the immune microenvironment of locally advanced cancers
- Ist Teil von
- Oncoimmunology, 2021-01, Vol.10 (1), p.1950954-1950954
- Ort / Verlag
- United States: Taylor & Francis
- Erscheinungsjahr
- 2021
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- Malignant cells adapt to the hostile tumor microenvironment by escaping from, or actively suppressing, anticancer immune responses. In the past, we reported that reduced synthesis of active vitamin B6 (due to downregulation of pyridoxal kinase) or overactivation of poly(ADP-ribose) polymerase confers resistance to chemotherapy with cisplatin. Recently, we found that these prognostically adverse alterations in oncometabolism also correlate with the rarefaction of immune effectors in the tumor bed.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 2162-402X, 2162-4011eISSN: 2162-402XDOI: 10.1080/2162402X.2021.1950954Titel-ID: cdi_pubmed_primary_34290910
- Format
- –
- Schlagworte
- Author’s View, Cancer, CD8+ T cells, cervical cancer, Cisplatin - therapeutic use, dendritic cells, Humans, immune escape, Immunology, immunotherapy, Life Sciences, Medicin och hälsovetenskap, metabolism, Neoplasms - drug therapy, Neoplasms - immunology, non-small cell lung cancer, Poly Adenosine Diphosphate Ribose, Poly(ADP-ribose) Polymerases, Pyridoxal Kinase, survival, Tumor microenvironment, Tumor Microenvironment - immunology, vitamin B