Details

Autor(en) / Beteiligte

• Minnier, Jessica
• Emmett, Mark R
• Perez, Ruby
• Ding, Liang-Hao
• Barnette, Brooke L
• Larios, Rianna E
• Hong, Changjin
• Hwang, Tae Hyun
• Yu, Yongjia
• Fallgren, Christina M
• Story, Michael D
• Weil, Michael M
• Raber, Jacob

Titel

Associations between lipids in selected brain regions, plasma miRNA, and behavioral and cognitive measures following 28 Si ion irradiation

Ist Teil von

• Scientific reports, 2021-07, Vol.11 (1), p.14899

Ort / Verlag

England

Erscheinungsjahr

2021

Quelle

MEDLINE

Beschreibungen/Notizen

• The space radiation environment consists of multiple species of charged particles, including Si ions, that may impact brain function during and following missions. To develop biomarkers of the space radiation response, BALB/c and C3H female and male mice and their F2 hybrid progeny were irradiated with Si ions (350 MeV/n, 0.2 Gy) and tested for behavioral and cognitive performance 1, 6, and 12 months following irradiation. The plasma of the mice was collected for analysis of miRNA levels. Select pertinent brain regions were dissected for lipidomic analyses and analyses of levels of select biomarkers shown to be sensitive to effects of space radiation in previous studies. There were associations between lipids in select brain regions, plasma miRNA, and cognitive measures and behavioral following Si ion irradiation. Different but overlapping sets of miRNAs in plasma were found to be associated with cognitive measures and behavioral in sham and irradiated mice at the three time points. The radiation condition revealed pathways involved in neurodegenerative conditions and cancers. Levels of the dendritic marker MAP2 in the cortex were higher in irradiated than sham-irradiated mice at middle age, which might be part of a compensatory response. Relationships were also revealed with CD68 in miRNAs in an anatomical distinct fashion, suggesting that distinct miRNAs modulate neuroinflammation in different brain regions. The associations between lipids in selected brain regions, plasma miRNA, and behavioral and cognitive measures following Si ion irradiation could be used for the development of biomarker of the space radiation response.