Details

Autor(en) / Beteiligte

• Alfaro, Javier Antonio
• Bohländer, Peggy
• Dai, Mingjie
• Filius, Mike
• Howard, Cecil J
• van Kooten, Xander F
• Ohayon, Shilo
• Pomorski, Adam
• Schmid, Sonja
• Aksimentiev, Aleksei
• Anslyn, Eric V
• Bedran, Georges
• Cao, Chan
• Chinappi, Mauro
• Coyaud, Etienne
• Dekker, Cees
• Dittmar, Gunnar
• Drachman, Nicholas
• Eelkema, Rienk
• Goodlett, David
• Hentz, Sébastien
• Kalathiya, Umesh
• Kelleher, Neil L
• Kelly, Ryan T
• Kelman, Zvi
• Kim, Sung Hyun
• Kuster, Bernhard
• Rodriguez-Larrea, David
• Lindsay, Stuart
• Maglia, Giovanni
• Marcotte, Edward M
• Marino, John P
• Masselon, Christophe
• Mayer, Michael
• Samaras, Patroklos
• Sarthak, Kumar
• Sepiashvili, Lusia
• Stein, Derek
• Wanunu, Meni
• Wilhelm, Mathias
• Yin, Peng
• Meller, Amit
• Joo, Chirlmin

Titel

The emerging landscape of single-molecule protein sequencing technologies

Ist Teil von

• Nature methods, 2021-06, Vol.18 (6), p.604

Ort / Verlag

United States

Erscheinungsjahr

2021

Quelle

MEDLINE

Beschreibungen/Notizen

• Single-cell profiling methods have had a profound impact on the understanding of cellular heterogeneity. While genomes and transcriptomes can be explored at the single-cell level, single-cell profiling of proteomes is not yet established. Here we describe new single-molecule protein sequencing and identification technologies alongside innovations in mass spectrometry that will eventually enable broad sequence coverage in single-cell profiling. These technologies will in turn facilitate biological discovery and open new avenues for ultrasensitive disease diagnostics.