The American journal of dermatopathology, 2021-10, Vol.43 (10), p.746-749
2021
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Papillary Dermal Elastolysis Secondary to Combination Nivolumab and Cabiralizumab Therapy: Histiocytes and Dermal Mucin as Clues to the Diagnosis
- Ist Teil von
- The American journal of dermatopathology, 2021-10, Vol.43 (10), p.746-749
- Ort / Verlag
- United States
- Erscheinungsjahr
- 2021
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Papillary dermal elastolysis has been described in the setting of experimental combination nivolumab and cabiralizumab immunotherapy. We report a third patient with distinctive, generalized atrophic macules that developed after a morbilliform eruption during a clinical trial for treatment of metastatic pancreatic adenocarcinoma. Histopathological findings demonstrated diminished elastic fibers in the papillary dermis, associated with a histiocyte-rich infiltrate and increased dermal mucin, features that should clue the dermatopathologist to this condition.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0193-1091eISSN: 1533-0311DOI: 10.1097/DAD.0000000000001915Titel-ID: cdi_pubmed_primary_34086644
- Format
- –
- Schlagworte
- Adenocarcinoma - drug therapy, Adenocarcinoma - secondary, Antineoplastic Combined Chemotherapy Protocols - adverse effects, Dermis - pathology, Drug Eruptions - diagnosis, Drug Eruptions - etiology, Drug Eruptions - metabolism, Drug Eruptions - pathology, Drug Therapy, Combination - adverse effects, Elastic Tissue - pathology, Histiocytes - pathology, Humans, Male, Middle Aged, Mucins - metabolism, Nivolumab - administration & dosage, Pancreatic Neoplasms - pathology