Voprosy meditsinskoi khimii, 1988-03, Vol.34 (2), p.97
1988
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Details
- Autor(en) / Beteiligte
- Titel
- Lysosomal hydrolase activity of the rat liver, spleen and thymus during antigenic stimulation and vitamin B6 deficiency
- Ist Teil von
- Voprosy meditsinskoi khimii, 1988-03, Vol.34 (2), p.97
- Ort / Verlag
- Russia (Federation)
- Erscheinungsjahr
- 1988
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Activity of cathepsins A, B, C and D and protein half-life T1/2 in rat liver, spleen and thymus tissues, content of antibody-producing cells in spleen, titer of antibodies and the complement activity were studied after antigen stimulation accompanied by vitamin B6 deficiency. Deficiency of vitamin B6 caused a distinct decrease in immune response and in activation of thiol-dependent proteinases in thymus, while the enzymatic activity was lowered in liver tissue. At the same time, the protein T1/2 was increased by 39% in liver tissue and decreased by 36% in thymus. These data suggest the importance of lysosomal thiol-dependent proteinases in immunogenesis.
- Sprache
- Russisch
- Identifikatoren
- ISSN: 0042-8809Titel-ID: cdi_pubmed_primary_3400200
- Format
- –
- Schlagworte
- Animals, Antibody-Producing Cells - immunology, Complement System Proteins - analysis, Half-Life, Hydrolases - metabolism, Immunization, Liver - enzymology, Lysosomes - enzymology, Male, Rats, Rats, Inbred Strains, Spleen - enzymology, Thymus Gland - enzymology, Vitamin B 6 Deficiency - enzymology, Vitamin B 6 Deficiency - immunology