Endocrine research, 1988, Vol.14 (1), p.21-33
1988
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Details
- Autor(en) / Beteiligte
- Titel
- Inhibition of Human Placental Microsomal Aromatase by Thyroid Hormone and Iodothyronine Derivatives
- Ist Teil von
- Endocrine research, 1988, Vol.14 (1), p.21-33
- Ort / Verlag
- Monticello, NY: Informa Healthcare USA, Inc
- Erscheinungsjahr
- 1988
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The initial velocity kinetics of the effect of thyroid hormone and analogs on human placental microsomal aromatase were studied. Thyroxine and its propionic analog 3,5,3′,5′-tetraiodothyropropionic acid show a competitive inhibition with an apparent K1 of 1.4 uM and 8.5 uM, respectively, towards androstenedione aromatization. 3,5,3′-Triiodothyronine with a K1 of 1.8 uM shows a decreased affinity compared to thyroxine. Two analogs, 3,5,3′-triiodothyropropionic acid and 3,5,3′-triiodothyroacetic acid appear to have negligible competition.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0743-5800eISSN: 1532-4206DOI: 10.1080/07435808809036337Titel-ID: cdi_pubmed_primary_3391136
- Format
- –
- Schlagworte
- Aromatase Inhibitors, Binding, Competitive, Biological and medical sciences, Female, Fundamental and applied biological sciences. Psychology, Hormone metabolism and regulation, Humans, Microsomes - enzymology, Placenta - enzymology, Pregnancy, Pregnancy. Parturition. Lactation, Thyroxine - analogs & derivatives, Thyroxine - pharmacology, Triiodothyronine - analogs & derivatives, Triiodothyronine - pharmacology, Vertebrates: reproduction