Details

Autor(en) / Beteiligte

• Leija-Martínez, José J
• Del-Río-Navarro, Blanca E
• Sanchéz-Muñoz, Fausto
• Muñoz-Hernández, Onofre
• Hong, Enrique
• Giacoman-Martínez, Abraham
• Romero-Nava, Rodrigo
• Patricio-Román, Karla L
• Hall-Mondragon, Margareth S
• Espinosa-Velazquez, Dario
• Villafaña, Santiago
• Huang, Fengyang

Titel

TNFA, IL17A and RORC mRNA expression levels as potential biomarkers of non-allergic asthma among adolescents with obesity

Ist Teil von

• Clinical immunology (Orlando, Fla.), 2021-03, p.108715

Ort / Verlag

United States

Erscheinungsjahr

2021

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Obesity is associated with a non-T2 asthma phenotype which is clinically more severe and difficult to control. Unfortunately, physicians have no gold standard biomarker to predict non-allergic asthma among obese patients. To evaluate the ability of TNFA, IL17A and RORC mRNA expression to predict non-allergic asthma among obese adolescents. This investigation was a cross-sectional study involving 4 adolescent groups: 1) healthy adolescents (n = 23), 2) adolescents with allergic asthma without obesity (n = 29), 3) adolescents with obesity without asthma (n = 28), and 4) adolescents with non-allergic asthma with obesity (n = 22). Receiver operating characteristic (ROC) curve analysis, the areas under the ROC curve (AUCs) for RORC, IL17A, and TNFA mRNA expression were 0.955 (95% CI: 0.86-0.99, p < 0.0001), 0.856 (95% CI: 0.73-0.94, p < 0.0001), and 0.756 (95% CI: 0.62-0.87, p = 0.0009), respectively. RORC, IL17A and TNFA mRNA expression levels may be potential biomarkers of non-allergic asthma among obese adolescents in clinical practice.