Details

Autor(en) / Beteiligte

• Zhang, Ning-Jing
• Fu, Yu-Zhe
• Shan, Xiao-Dong
• Zhang, Ning
• Sun, Xi-Tai
• Chu, Xue-Hui
• Bi, Yan
• Zhu, Da-Long
• Feng, Wen-Huan

Titel

Are Chinese Patients with Type 2 Diabetes and a Body Mass Index of 27.5-32.5 kg/m 2 Suitable for Metabolic Surgery? A One-Year Post-Surgery Study

Ist Teil von

• Diabetes therapy, 2021-05, Vol.12 (5), p.1429

Ort / Verlag

United States

Erscheinungsjahr

2021

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• The aim of this study was to clarify the efficacy and safety of metabolic surgery in Chinese patients with type 2 diabetes mellitus (T2DM) and a body mass index (BMI) of 27.5-32.5 kg/m . A total of 99 patients with T2DM were enrolled in this retrospective cohort study. Of these patients, 53 had a BMI of 27.5-32.5 kg/m and had undergone metabolic surgery (n = 21) or were on conventional antidiabetic therapy (n = 32)]; 46 had a BMI ≥ 32.5 kg/m and all had undergone metabolic surgery. Primary endpoints included the triple endpoint [hemoglobin A1c < 6.5%, low-density lipoprotein cholesterol (LDL-C) < 2.6 mmol/L, and systolic blood pressure (SBP) < 130 mmHg] and successful weight loss 1 year later. Remission of diabetes, glucose and lipid metabolism, medication usage, and adverse events were evaluated. Of patients with BMI 27.5-32.5 kg/m undergoing metabolic surgery, 33.33% achieved the composite endpoints, and 100% achieved successful weight loss. This result was similar to that in patients with BMI ≥ 32.5 and better than those with BMI 27.5-32.5 kg/m receiving conventional antidiabetic therapy. A significant and similar reduction in BMI, waist circumference, SBP, serum LDL-C, hemoglobin A1c, and uric acid, as well as similar frequency postoperative adverse events, were confirmed in both metabolic surgery groups. Patients with BMI 27.5-32.5 kg/m who had undergonemetabolic surgery showed more metabolic improvement than those only receiving medications but they experienced more adverse events. A BMI cutoff of 27.5 kg/m for metabolic surgery may be suitable for Chinese patients with T2DM.