Trends in Cancer, 2021-07, Vol.7 (7), p.606-623
2021
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- Autor(en) / Beteiligte
- Titel
- Liver Inflammation and Hepatobiliary Cancers
- Ist Teil von
- Trends in Cancer, 2021-07, Vol.7 (7), p.606-623
- Ort / Verlag
- United States
- Erscheinungsjahr
- 2021
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Immune regulation has an important role in cancer development, particularly in organs with continuous exposure to environmental pathogens, such as the liver and gastrointestinal tract. Chronic liver inflammation can lead to the development of hepatobiliary cancers, namely hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (iCCA), or combined HCC (cHCC)-CCA. In this review, we discuss the link between oxidative stress and the hepatic immune compartments, as well as how these factors trigger hepatocyte damage, proliferation, and eventually cancer initiation and its sustainment. We further give an overview of new anticancer therapies based on immunomodulation.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 2405-8033eISSN: 2405-8025DOI: 10.1016/j.trecan.2021.01.012Titel-ID: cdi_pubmed_primary_33674229
- Format
- –
- Schlagworte
- Antineoplastic Agents, Immunological - pharmacology, Antineoplastic Agents, Immunological - therapeutic use, Antineoplastic Combined Chemotherapy Protocols - pharmacology, Antineoplastic Combined Chemotherapy Protocols - therapeutic use, Apoptosis - immunology, Bile Duct Neoplasms - immunology, Bile Duct Neoplasms - mortality, Bile Duct Neoplasms - pathology, Bile Duct Neoplasms - therapy, Bile Ducts, Intrahepatic - immunology, Bile Ducts, Intrahepatic - pathology, Cancer Vaccines - therapeutic use, Carcinogenesis - drug effects, Carcinogenesis - immunology, Clinical Trials as Topic, Hepatitis, Chronic - complications, Hepatitis, Chronic - immunology, Hepatitis, Chronic - pathology, Hepatocytes - pathology, Humans, Immune Checkpoint Inhibitors - pharmacology, Immune Checkpoint Inhibitors - therapeutic use, Immunity, Innate, Immunotherapy - methods, Liver - immunology, Liver - pathology, Liver Neoplasms - immunology, Liver Neoplasms - mortality, Liver Neoplasms - pathology, Liver Neoplasms - therapy, Necroptosis - immunology, Oxidative Stress - immunology, Progression-Free Survival, Reactive Oxygen Species - metabolism