Details

Autor(en) / Beteiligte

• Krishnan, Siddharth R
• Arafa, Hany M
• Kwon, Kyeongha
• Deng, Yujun
• Su, Chun-Ju
• Reeder, Jonathan T
• Freudman, Juliet
• Stankiewicz, Izabela
• Chen, Hsuan-Ming
• Loza, Robert
• Mims, Marcus
• Mims, Mitchell
• Lee, KunHyuck
• Abecassis, Zachary
• Banks, Aaron
• Ostojich, Diana
• Patel, Manish
• Wang, Heling
• Börekçi, Kaan
• Rosenow, Joshua
• Tate, Matthew
• Huang, Yonggang
• Alden, Tord
• Potts, Matthew B
• Ayer, Amit B
• Rogers, John A

Titel

Continuous, noninvasive wireless monitoring of flow of cerebrospinal fluid through shunts in patients with hydrocephalus

Ist Teil von

• NPJ digital medicine, 2020-03, Vol.3 (1), p.29

Ort / Verlag

England

Erscheinungsjahr

2020

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Hydrocephalus is a common disorder caused by the buildup of cerebrospinal fluid (CSF) in the brain. Treatment typically involves the surgical implantation of a pressure-regulated silicone tube assembly, known as a shunt. Unfortunately, shunts have extremely high failure rates and diagnosing shunt malfunction is challenging due to a combination of vague symptoms and a lack of a convenient means to monitor flow. Here, we introduce a wireless, wearable device that enables precise measurements of CSF flow, continuously or intermittently, in hospitals, laboratories or even in home settings. The technology exploits measurements of thermal transport through near-surface layers of skin to assess flow, with a soft, flexible, and skin-conformal device that can be constructed using commercially available components. Systematic benchtop studies and numerical simulations highlight all of the key considerations. Measurements on 7 patients establish high levels of functionality, with data that reveal time dependent changes in flow associated with positional and inertial effects on the body. Taken together, the results suggest a significant advance in monitoring capabilities for patients with shunted hydrocephalus, with potential for practical use across a range of settings and circumstances, and additional utility for research purposes in studies of CSF hydrodynamics.