Details

Autor(en) / Beteiligte

• Mütze, Ulrike
• Walter, Magdalena
• Keller, Mareike
• Gramer, Gwendolyn
• Garbade, Sven F
• Gleich, Florian
• Haas, Dorothea
• Posset, Roland
• Grünert, Sarah C
• Hennermann, Julia B
• Thimm, Eva
• Fang-Hoffmann, Junmin
• Syrbe, Steffen
• Okun, Jürgen G
• Hoffmann, Georg F
• Kölker, Stefan

Titel

Health Outcomes of Infants with Vitamin B 12 Deficiency Identified by Newborn Screening and Early Treated

Ist Teil von

• The Journal of pediatrics, 2021-08

Ort / Verlag

United States

Erscheinungsjahr

2021

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• To evaluate the clinical outcomes at age 1.5 ± 0.5 years of infants with vitamin B deficiency identified by newborn screening (NBS). Prospective multicenter observational study on health outcomes of 31 infants with vitamin B deficiency identified by NBS. Neurodevelopment was assessed by the Denver Developmental Screening Test. In 285 862 newborns screened between 2016 and 2019, the estimated birth prevalence of vitamin B deficiency was 26 in 100 000 newborns, with high seasonal variations (lowest in summer: 8 in 100 000). Infants participating in the outcome study (N = 31) were supplemented with vitamin B for a median (range) of 5.9 (1.1-16.2) months. All achieved age-appropriate test results in Denver Developmental Screening Test at age 15 (11-23) months and did not present with symptoms characteristic for vitamin B deficiency. Most (81%, n = 25) mothers of affected newborns had a hitherto undiagnosed (functional) vitamin B deficiency, and, subsequently, received specific therapy. Neonatal vitamin B deficiency can be screened by NBS, preventing the manifestation of irreversible neurologic symptoms and the recurrence of vitamin B deficiency in future pregnancies through adequate treatment of affected newborns and their mothers. The high frequency of mothers with migrant background having a newborn with vitamin B deficiency highlights the need for improved prenatal care.