Details

Autor(en) / Beteiligte

• Yang, Qilin
• Zhang, Yinzhou
• Kong, Tianyu
• Chen, Xiaohua
• Chen, Weiyan
• Liu, Weijiang
• Zhang, Zhenhui
• Xiong, Xuming
• Wen, Deliang
• Chen, Xiaohui

Titel

The interaction between soluble CD73 and 90-day mortality from patients with non-septic shock and sepsis shock: a secondary analysis from the prospective FINNAKI study

Ist Teil von

• Zhonghua wei zhong bing ji jiu yi xue, 2020-12, Vol.32 (12), p.1434

Ort / Verlag

China

Erscheinungsjahr

2020

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Fundamental researches have shown that soluble CD73 (sCD73) can inhibit inflammatory response and limit excessive tissue damage caused by continuous immune cell activation. A Finnish prospective, observational study of acute kidney injury (FINNAKI) showed no association between sCD73 and 90-day mortality in sepsis patients. Clinical data of this study was used for secondary analysis to explore whether the relationship between sCD73 and 90-day mortality was consistent in septic shock and non-septic shock patients. The FINNAKI study was a prospective, observational cohort study conducted in 17 intensive care units (ICUs) in Finland from September 1st, 2011 to February 1st, 2012. Sepsis/septic shock was defined according to Sepsis-1 definition. Demographic characteristics, treatment, comorbidities and 90-day mortality of the patients were analyzed. To evaluate the difference (interaction test) between the relationship of sCD73 and 90-day mortality in septic shock and non-septic shock patients, likelihood ratio t