Details

Autor(en) / Beteiligte

• Savino, Angela Maria
• Fernandes, Sara Isabel
• Olivares, Orianne
• Zemlyansky, Anna
• Cousins, Antony
• Markert, Elke K
• Barel, Shani
• Geron, Ifat
• Frishman, Liron
• Birger, Yehudit
• Eckert, Cornelia
• Tumanov, Sergey
• MacKay, Gillian
• Kamphorst, Jurre J
• Herzyk, Pawel
• Fernández-García, Jonatan
• Abramovich, Ifat
• Mor, Inbal
• Bardini, Michela
• Barin, Ersilia
• Janaki-Raman, Sudha
• Cross, Justin R
• Kharas, Michael G
• Gottlieb, Eyal
• Izraeli, Shai
• Halsey, Christina

Titel

Metabolic adaptation of acute lymphoblastic leukemia to the central nervous system microenvironment is dependent on Stearoyl CoA desaturase

Ist Teil von

• Nature cancer, 2020-10, Vol.1 (10), p.998

Ort / Verlag

England

Erscheinungsjahr

2020

Quelle

MEDLINE

Beschreibungen/Notizen

• Metabolic reprogramming is a key hallmark of cancer, but less is known about metabolic plasticity of the same tumor at different sites. Here, we investigated the metabolic adaptation of leukemia in two different microenvironments, the bone marrow and the central nervous system (CNS). We identified a metabolic signature of fatty-acid synthesis in CNS leukemia, highlighting Stearoyl-CoA desaturase ( ) as a key player. SCD1 overexpression increases CNS disease, whilst genetic or pharmacological inhibition of SCD1 decreases CNS load. Overall, we demonstrated that leukemic cells dynamically rewire metabolic pathways to suit local conditions and that targeting these adaptations can be exploited therapeutically.