Details

Autor(en) / Beteiligte

• Xu, Zhaoyuan
• Ji, Guohua
• Cui, Ying
• Cui, Xiaobo

Titel

The Impacts of Non-coding RNAs and N 6 -Methyladenosine on Cancer: Past, Present and Future

Ist Teil von

• Current cancer drug targets, 2021, Vol.21 (5), p.375

Ort / Verlag

Netherlands

Erscheinungsjahr

2021

Quelle

MEDLINE

Beschreibungen/Notizen

• N6-methyladenosine (m A) modifications control multifaceted RNA metabolism and are one of the most extensively distributed modifications on the human transcriptome, including non-coding RNAs (ncRNAs). Previous concepts of ncRNAs as "junk" transcriptional products have evolved to the concept that ncRNAs are functional regulatory molecules that determine specific biological processes and cell fates. The dysregulation of m A modifications and ncRNAs have been implicated in the development of human carcinogenesis. Certain types of ncRNAs have been reported to exert regulatory effects on m A machinery. However, a better understanding of the relationship between m A modifications and ncRNAs in cancer is still needed. This review discusses mutual interactions between m A modifications and ncRNAs and their impacts on the development of human cancer. We summarize the clinical significance of m A-ncRNA networks for cancer diagnosis and treatment, and we ask challenging questions that remain unanswered in this field of research. Understanding the complex coordination between m A modifications and ncRNAs will be useful for guiding the development of therapeutic interventions.