Details

Autor(en) / Beteiligte

• Trelle, Alexandra N
• Carr, Valerie A
• Wilson, Edward N
• Swarovski, Michelle S
• Hunt, Madison P
• Toueg, Tyler N
• Tran, Tammy T
• Channappa, Divya
• Corso, Nicole K
• Thieu, Monica K
• Jayakumar, Manasi
• Nadiadwala, Ayesha
• Guo, Wanjia
• Tanner, Natalie J
• Bernstein, Jeffrey D
• Litovsky, Celia P
• Guerin, Scott A
• Khazenzon, Anna M
• Harrison, Marc B
• Rutt, Brian K
• Deutsch, Gayle K
• Chin, Frederick T
• Davidzon, Guido A
• Hall, Jacob N
• Sha, Sharon J
• Fredericks, Carolyn A
• Andreasson, Katrin I
• Kerchner, Geoffrey A
• Wagner, Anthony D
• Mormino, Elizabeth C

Titel

Association of CSF Biomarkers With Hippocampal-Dependent Memory in Preclinical Alzheimer Disease

Ist Teil von

• Neurology, 2021-03, Vol.96 (10), p.e1470

Ort / Verlag

United States

Erscheinungsjahr

2021

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• To determine whether memory tasks with demonstrated sensitivity to hippocampal function can detect variance related to preclinical Alzheimer disease (AD) biomarkers, we examined associations between performance in 3 memory tasks and CSF β-amyloid (Aβ) /Aβ and phosopho-tau (p-tau ) in cognitively unimpaired older adults (CU). CU enrolled in the Stanford Aging and Memory Study (n = 153; age 68.78 ± 5.81 years; 94 female) completed a lumbar puncture and memory assessments. CSF Aβ , Aβ , and p-tau were measured with the automated Lumipulse G system in a single-batch analysis. Episodic memory was assayed using a standardized delayed recall composite, paired associate (word-picture) cued recall, and a mnemonic discrimination task that involves discrimination between studied "target" objects, novel "foil" objects, and perceptually similar "lure" objects. Analyses examined cross-sectional relationships among memory performance, age, and CSF measures, controlling for sex and education. Age and lower Aβ /Aβ were independently associated with elevated p-tau . Age, Aβ /Aβ , and p-tau were each associated with (1) poorer associative memory and (2) diminished improvement in mnemonic discrimination performance across levels of decreased task difficulty (i.e., target-lure similarity). P-tau mediated the effect of Aβ /Aβ on memory. Relationships between CSF proteins and delayed recall were similar but nonsignificant. CSF Aβ was not significantly associated with p-tau or memory. Tests designed to tax hippocampal function are sensitive to subtle individual differences in memory among CU and correlate with early AD-associated biomarker changes in CSF. These tests may offer utility for identifying CU with preclinical AD pathology.