Details

Autor(en) / Beteiligte

• Fernandes Matuck, Bruno
• Dolhnikoff, Marisa
• Maia, Gilvan V. A.
• Isaac Sendyk, Daniel
• Zarpellon, Amanda
• Costa Gomes, Sara
• Duarte-Neto, Amaro Nunes
• Rebello Pinho, João Renato
• Gomes-Gouvêa, Michele Soares
• Sousa, Suzana C.O. M.
• Mauad, Thais
• Saldiva, Paulo Hilário do Nascimento
• Braz-Silva, Paulo H.
• Silva, Luiz Fernando Ferraz da

Titel

Periodontal tissues are targets for Sars-Cov-2: a post-mortem study

Ist Teil von

• Journal of oral microbiology, 2021-01, Vol.13 (1), p.1848135-1848135

Ort / Verlag

United States: Taylor & Francis

Erscheinungsjahr

2021

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Background: The ability of coronavirus SARS-CoV-2 to spread is one of the determinants of the COVID-19 pandemic status. Until June 2020, global COVID-19 cases surpassed 10 million. Asymptomatic patients, with no respiratory impairment, are believed to be responsible for more than 80% of the transmission. Other viruses have been consistently detected in periodontal tissues. Objective: The aim of this study was to investigate the presence of SARS-CoV-2 in periodontal tissue. Methods: We conducted video-endoscope minimally invasive post-mortem biopsy in seven fatal cases of COVID-19, using a regular endoscope video system associated with a smartphone to locate periodontal tissue. We analyzed the samples using RT-PCR, to identify the SARS-CoV-2 RNA and histopathological analysis. Results: The seven studied autopsies with positive laboratory tests for COVID-19 included 57.14% of female patients at the average age of 47.4 (range 8 to 74). In five cases, periodontal tissue was positive for SARS-CoV-2 (RT-PCR). Histopathologic analyses showed morphologic alterations in the keratinocytes of the junctional epithelium, a vacuolization of the cytoplasm and nucleus and nuclear pleomorphism. Conclusion: We presented a biomolecular analysis obtained from minimally invasive autopsies. This is the first study to demonstrate the presence of SARS-CoV-2 in periodontal tissue in COVID-19 positive patients.