Details

Autor(en) / Beteiligte

• Maev, I V
• Andreev, D N
• Govorun, V M
• Ilina, E N
• Kucheryavyy, Y A
• Oganesian, T S
• Melnikova, E V
• Zayratyants, O V
• Parfenova, T V
• Dzhedzheia, L V
• Kirillova, N V
• Maevskaya, E A
• Fomenko, A K
• Lobanova, E G
• Zaborovskii, A V
• Kriukov, K A

Titel

Antibiotic resistance of Helicobacter pylori in the European part of the Russian Federation: first results

Ist Teil von

• Terapevtic̆eskii arhiv, 2020-09, Vol.92 (8), p.24

Ort / Verlag

Russia (Federation)

Erscheinungsjahr

2020

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Determine the primary antibiotic resistance of Helicobacter pylori (H. pylori) strains isolated from patients living in the European part of the Russian Federation. As part of a clinical laboratory study, from 2015 to 2018, 27 gastrobiopsy samples obtained from H. pylori-infected patients were analyzed. H. pylori infection was verified using a rapid urease test or a 13C-urea breath test. The values of the minimum inhibitory concentration (MIC) of antibiotics were determined by the diffusion method using E-test strips (BioMerieux, France) according to the recommendations of the manufacturer. The sensitivity of the isolates was determined for 6 antibacterial drugs (amoxicillin, clarithromycin, metronidazole, levofloxacin, tetracycline, rifampicin). According to the data obtained, resistance to amoxicillin was 0%, clarithromycin 11.1%, metronidazole 59.3%, levofloxacin 3.7%, tetracycline 0%, and rifampicin 14.8%. Dual resistance to clarithromycin and metronidazole was recorded in two isolates (7.4%). Thus, the first results of the evaluation of H. pylori antibiotic resistance in the European part of the Russian Federation indicate a low resistance of the microorganism to clarithromycin and quite high to metronidazole.