Details

Autor(en) / Beteiligte

• Weisberg, Stuart P
• Connors, Thomas J
• Zhu, Yun
• Baldwin, Matthew R
• Lin, Wen-Hsuan
• Wontakal, Sandeep
• Szabo, Peter A
• Wells, Steven B
• Dogra, Pranay
• Gray, Joshua
• Idzikowski, Emma
• Stelitano, Debora
• Bovier, Francesca T
• Davis-Porada, Julia
• Matsumoto, Rei
• Poon, Maya Meimei Li
• Chait, Michael
• Mathieu, Cyrille
• Horvat, Branka
• Decimo, Didier
• Hudson, Krystalyn E
• Zotti, Flavia Dei
• Bitan, Zachary C
• La Carpia, Francesca
• Ferrara, Stephen A
• Mace, Emily
• Milner, Joshua
• Moscona, Anne
• Hod, Eldad
• Porotto, Matteo
• Farber, Donna L

Titel

Distinct antibody responses to SARS-CoV-2 in children and adults across the COVID-19 clinical spectrum

Ist Teil von

• Nature immunology, 2021-01, Vol.22 (1), p.25

Ort / Verlag

United States

Erscheinungsjahr

2021

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Clinical manifestations of COVID-19 caused by the new coronavirus SARS-CoV-2 are associated with age . Adults develop respiratory symptoms, which can progress to acute respiratory distress syndrome (ARDS) in the most severe form, while children are largely spared from respiratory illness but can develop a life-threatening multisystem inflammatory syndrome (MIS-C) . Here, we show distinct antibody responses in children and adults after SARS-CoV-2 infection. Adult COVID-19 cohorts had anti-spike (S) IgG, IgM and IgA antibodies, as well as anti-nucleocapsid (N) IgG antibody, while children with and without MIS-C had reduced breadth of anti-SARS-CoV-2-specific antibodies, predominantly generating IgG antibodies specific for the S protein but not the N protein. Moreover, children with and without MIS-C had reduced neutralizing activity as compared to both adult COVID-19 cohorts, indicating a reduced protective serological response. These results suggest a distinct infection course and immune response in children independent of whether they develop MIS-C, with implications for developing age-targeted strategies for testing and protecting the population.