Details

Autor(en) / Beteiligte

• Thorball, Christian W
• Borghesi, Alessandro
• Bachmann, Nadine
• Von Siebenthal, Chantal
• Vongrad, Valentina
• Turk, Teja
• Neumann, Kathrin
• Beerenwinkel, Niko
• Bogojeska, Jasmina
• Roth, Volker
• Kok, Yik Lim
• Parbhoo, Sonali
• Wieser, Mario
• Böni, Jürg
• Perreau, Matthieu
• Klimkait, Thomas
• Yerly, Sabine
• Battegay, Manuel
• Rauch, Andri
• Schmid, Patrick
• Bernasconi, Enos
• Cavassini, Matthias
• Kouyos, Roger D
• Günthard, Huldrych F
• Metzner, Karin J
• Fellay, Jacques

Titel

Host Genomics of the HIV-1 Reservoir Size and Its Decay Rate During Suppressive Antiretroviral Treatment

Ist Teil von

• Journal of acquired immune deficiency syndromes (1999), 2020-12, Vol.85 (4), p.517

Ort / Verlag

United States

Erscheinungsjahr

2020

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• The primary hurdle for the eradication of HIV-1 is the establishment of a latent viral reservoir early after primary infection. Here, we investigated the potential influence of human genetic variation on the HIV-1 reservoir size and its decay rate during suppressive antiretroviral treatment. Genome-wide association study and exome sequencing study to look for host genetic determinants of HIV-1 reservoir measurements in patients enrolled in the Swiss HIV Cohort Study, a nation-wide prospective observational study. We measured total HIV-1 DNA in peripheral blood mononuclear cells from study participants, as a proxy for the reservoir size at 3 time points over a median of 5.4 years, and searched for associations between human genetic variation and 2 phenotypic readouts: the reservoir size at the first time point and its decay rate over the study period. We assessed the contribution of common genetic variants using genome-wide genotyping data from 797 patients with European ancestry enrolled in the Swiss HIV Cohort Study and searched for a potential impact of rare variants and exonic copy number variants using exome sequencing data generated in a subset of 194 study participants. Genome-wide and exome-wide analyses did not reveal any significant association with the size of the HIV-1 reservoir or its decay rate on suppressive antiretroviral treatment. Our results point to a limited influence of human genetics on the size of the HIV-1 reservoir and its long-term dynamics in successfully treated individuals.