Details

Autor(en) / Beteiligte

• Moutal, Aubin
• Martin, Laurent F
• Boinon, Lisa
• Gomez, Kimberly
• Ran, Dongzhi
• Zhou, Yuan
• Stratton, Harrison J
• Cai, Song
• Luo, Shizhen
• Gonzalez, Kerry Beth
• Perez-Miller, Samantha
• Patwardhan, Amol
• Ibrahim, Mohab M
• Khanna, Rajesh

Titel

SARS-CoV-2 spike protein co-opts VEGF-A/neuropilin-1 receptor signaling to induce analgesia

Ist Teil von

• Pain (Amsterdam), 2021-01, Vol.162 (1), p.243-252

Ort / Verlag

United States: Wolters Kluwer

Erscheinungsjahr

2021

Quelle

MEDLINE

Beschreibungen/Notizen

• Global spread of severe acute respiratory syndrome coronavirus 2 continues unabated. Binding of severe acute respiratory syndrome coronavirus 2's spike protein to host angiotensin-converting enzyme 2 triggers viral entry, but other proteins may participate, including the neuropilin-1 receptor (NRP-1). Because both spike protein and vascular endothelial growth factor-A (VEGF-A)-a pronociceptive and angiogenic factor, bind NRP-1, we tested whether spike could block VEGF-A/NRP-1 signaling. VEGF-A-triggered sensory neuron firing was blocked by spike protein and NRP-1 inhibitor EG00229. Pronociceptive behaviors of VEGF-A were similarly blocked through suppression of spontaneous spinal synaptic activity and reduction of electrogenic currents in sensory neurons. Remarkably, preventing VEGF-A/NRP-1 signaling was antiallodynic in a neuropathic pain model. A "silencing" of pain through subversion of VEGF-A/NRP-1 signaling may underlie increased disease transmission in asymptomatic individuals.