Details

Autor(en) / Beteiligte

• Foxa, Gabrielle E
• Liu, Ye
• Turner, Lisa M
• Robling, Alexander G
• Yang, Tao
• Williams, Bart O

Titel

Generation and Characterization of Mouse Models for Skeletal Disease

Ist Teil von

• Methods in molecular biology (Clifton, N.J.), 2021, Vol.2221, p.165

Ort / Verlag

United States

Erscheinungsjahr

2021

Quelle

MEDLINE

Beschreibungen/Notizen

• Our laboratories have used genetically engineered mouse models (GEMMs) to assess genetic contributions to skeletal diseases such as osteoporosis and osteoarthritis. Studies on the genetic contributions to OA are often done by assessing how GEMMs respond to surgical methods that induce symptoms modeling OA. Here, we will describe protocols outlining the induction of experimental OA in mice as well as detailed descriptions of methods for analyzing skeletal phenotypes using micro-computerized tomography and skeletal histomorphometry.