Details

Autor(en) / Beteiligte

• Arvanitaki, A
• Giannakoulas, G
• Triantafyllidou, E
• Karvounis, H
• Garyfallos, A
• Kitas, G
• Dimitroulas, T

Titel

Nailfold videocapillaroscopy: a novel possible surrogate marker for the evaluation of peripheral microangiopathy in pulmonary arterial hypertension

Ist Teil von

• Scandinavian journal of rheumatology, 2021-03, Vol.50 (2), p.85-94

Ort / Verlag

England: Taylor & Francis

Erscheinungsjahr

2021

Beschreibungen/Notizen

• Nailfold videocapillaroscopy (NVC) changes in systemic sclerosis (SSc) are correlated with vascular complications, such as pulmonary arterial hypertension (PAH), supporting a potential link between peripheral and internal organ vasculopathy. The current stage of knowledge regarding NVC and PAH is discussed, focusing on the assessment of peripheral microangiopathy and a potential relationship with functional, echocardiographic, and haemodynamic markers of cardiac dysfunction. A comprehensive literature search was carried out to identify all studies focusing on NVC findings in patients with PAH, diagnosed with right heart catheterization. The majority of the studies examined NVC findings in patients with SSc-PAH, while three studies reported NVC abnormalities in patients with idiopathic PAH. Besides the pulmonary vasculature, a systemic component of microangiopathy seems to be involved in PAH. Well-designed prospective trials are warranted to validate NVC as a biomarker, with clinical implications in the diagnostic evaluation, risk stratification, and overall management of PAH in the daily clinical setting.