Details

Autor(en) / Beteiligte

• Bolu, Abdullah
• Uzun, Özcan
• Burak Aydin, Mikail
• Ertuğrul, Sebla
• Öznur, Taner
• Çetinkaya, Serdar
• Erdem, Onur
• Nahit Özmenler, Kamil

Titel

Plasma prolidase levels are high in schizophrenia but not in first-episode psychosis

Ist Teil von

• International clinical psychopharmacology, 2021-01, Vol.36 (1), p.25-29

Ort / Verlag

England

Erscheinungsjahr

2021

Quelle

MEDLINE

Beschreibungen/Notizen

• An increasing number of studies have focussed on the neurobiology of schizophrenia (SCH), contributing to a better understanding of this disorder. Prolidase is a metalloprotease found in various tissues, which has been associated with the concentrations of proline, a neurotransmitter, in the brain. There is evidence to suggest that elevated proline levels play a role in SCH. The aim of the present study was to compare plasma proline levels in patients with drug-naive first-episode psychosis (FEP) and in those with SCH. Patients diagnosed with FEP (n = 26) and SCH (n = 26) were recruited for this study, in addition to healthy control volunteers (n = 26). Plasma prolidase levels were found to be elevated in the SCH group compared to drug-naive FEP and healthy control groups. This finding indicates that prolidase levels are higher in SCH patients, while levels in patients with drug-naive FEP are similar to those of healthy control. Follow-up studies are needed to provide a better understanding of prolidase in the etiopathogenesis of SCH.