Details

Autor(en) / Beteiligte

• Manickavinayaham, Swarnalatha
• Velez-Cruz, Renier
• Biswas, Anup K.
• Chen, Jie
• Guo, Ruifeng
• Johnson, David G.

Titel

The E2F1 transcription factor and RB tumor suppressor moonlight as DNA repair factors

Ist Teil von

• Cell cycle (Georgetown, Tex.), 2020-09, Vol.19 (18), p.2260-2269

Ort / Verlag

United States: Taylor & Francis

Erscheinungsjahr

2020

Link zum Volltext

Quelle

Taylor & Francis Journals Auto-Holdings Collection

Beschreibungen/Notizen

• The E2F1 transcription factor and RB tumor suppressor are best known for their roles in regulating the expression of genes important for cell cycle progression but, they also have transcription-independent functions that facilitate DNA repair at sites of damage. Depending on the type of DNA damage, E2F1 can recruit either the GCN5 or p300/CBP histone acetyltransferases to deposit different histone acetylation marks in flanking chromatin. At DNA double-strand breaks, E2F1 also recruits RB and the BRG1 ATPase to remodel chromatin and promote loading of the MRE11-RAD50-NBS1 complex. Knock-in mouse models demonstrate important roles for E2F1 post-translational modifications in regulating DNA repair and physiological responses to DNA damage. This review highlights how E2F1 moonlights in DNA repair, thus revealing E2F1 as a versatile protein that recruits many of the same chromatin-modifying enzymes to sites of DNA damage to promote repair that it recruits to gene promoters to regulate transcription.