Details

Autor(en) / Beteiligte

• Hiil, J L
• Kan, S K
• Parmar, S S
• Chan, M K
• Mak, J W
• Lim, P K
• Lim, T W
• Dennis, D T

Titel

The effect of diethylcarbamazine citrate on incidence and recovery rates of Brugia malayi microfilaremia in Sabah, Malaysia

Ist Teil von

• The American journal of tropical medicine and hygiene, 1988-05, Vol.38 (3), p.582

Ort / Verlag

United States

Erscheinungsjahr

1988

Quelle

MEDLINE

Beschreibungen/Notizen

• Mass drug administration via 3 modes of delivery reduced the incidence and prevalence rates and intensity of Brugia malayi infection in 3 rural villages in the Bengkoka Peninsula, Sabah, in 1982-1983. A dosage of 6 mg diethylcarbamazine citrate (DEC-C)/kg body weight was administered either daily or weekly (total of 6 doses, 36 mg/kg body weight), and impact on B. malayi cases were comparable in the 3 villages. A total of 384 people participated in the DEC-C regimens, and all pregnant women and children under 2 years were excluded from the study. Bekessy's method of estimation of incidence and recovery rates was applied to data on B. malayi microfilaremia before drug administration. Treatment with DEC-C by any of the 3 modes of delivery drastically reduced the number of episodes of patent microfilaremia, incidence and prevalence, and median microfilarial density. Reduction was sustained for at least 18 to 24 months after treatment.