Details

Autor(en) / Beteiligte

• Nishimukai, H
• Nakanishi, I
• Kitamura, H
• Tamaki, Y

Titel

Factor B subtypes in Japanese patients with IgA nephropathy and with idiopathic membranous nephropathy

Ist Teil von

• Experimental and clinical immunogenetics, 1988, Vol.5 (4), p.196

Ort / Verlag

Switzerland

Erscheinungsjahr

1988

Quelle

MEDLINE

Beschreibungen/Notizen

• The present paper describes a method of subtyping of properdin factor B (BF) using polyacrylamide gel isoelectric focusing followed by immunoblotting, and the distribution of BF subtypes in Japanese patients with IgA nephropathy or idiopathic membranous nephropathy (IMN) along with controls. BF*F allele was splitted into two suballeles, named BF*FA and BF*FB. There were significant differences in the BF suballele frequencies between the IMN patient group and the control group. A significant association of IMN with the BF FA subtype (p less than 0.05) and with the BF FB subtype (p less than 0.001) was also found. BF*FB may be a susceptibility suballele to IMN rather than BF*FA.