Details

Autor(en) / Beteiligte

• Braun, Julian
• Loyal, Lucie
• Frentsch, Marco
• Wendisch, Daniel
• Georg, Philipp
• Kurth, Florian
• Hippenstiel, Stefan
• Dingeldey, Manuela
• Kruse, Beate
• Fauchere, Florent
• Baysal, Emre
• Mangold, Maike
• Henze, Larissa
• Lauster, Roland
• Mall, Marcus A
• Beyer, Kirsten
• Röhmel, Jobst
• Voigt, Sebastian
• Schmitz, Jürgen
• Miltenyi, Stefan
• Demuth, Ilja
• Müller, Marcel A
• Hocke, Andreas
• Witzenrath, Martin
• Suttorp, Norbert
• Kern, Florian
• Reimer, Ulf
• Wenschuh, Holger
• Drosten, Christian
• Corman, Victor M
• Giesecke-Thiel, Claudia
• Sander, Leif Erik
• Thiel, Andreas

Titel

SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19

Ist Teil von

• Nature (London), 2020-11, Vol.587 (7833), p.270-274

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2020

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the rapidly unfolding coronavirus disease 2019 (COVID-19) pandemic . Clinical manifestations of COVID-19 vary, ranging from asymptomatic infection to respiratory failure. The mechanisms that determine such variable outcomes remain unresolved. Here we investigated CD4 T cells that are reactive against the spike glycoprotein of SARS-CoV-2 in the peripheral blood of patients with COVID-19 and SARS-CoV-2-unexposed healthy donors. We detected spike-reactive CD4 T cells not only in 83% of patients with COVID-19 but also in 35% of healthy donors. Spike-reactive CD4 T cells in healthy donors were primarily active against C-terminal epitopes in the spike protein, which show a higher homology to spike glycoproteins of human endemic coronaviruses, compared with N-terminal epitopes. Spike-protein-reactive T cell lines generated from SARS-CoV-2-naive healthy donors responded similarly to the C-terminal region of the spike proteins of the human endemic coronaviruses 229E and OC43, as well as that of SARS-CoV-2. This results indicate that spike-protein cross-reactive T cells are present, which were probably generated during previous encounters with endemic coronaviruses. The effect of pre-existing SARS-CoV-2 cross-reactive T cells on clinical outcomes remains to be determined in larger cohorts. However, the presence of spike-protein cross-reactive T cells in a considerable fraction of the general population may affect the dynamics of the current pandemic, and has important implications for the design and analysis of upcoming trials investigating COVID-19 vaccines.