Annals of surgery, 2020-08, Vol.272 (2), p.277
2020
Details
- Autor(en) / Beteiligte
- Titel
- Casting A Wide Net On Surgery: The Central Role of Neutrophil Extracellular Traps
- Ist Teil von
- Annals of surgery, 2020-08, Vol.272 (2), p.277
- Ort / Verlag
- United States
- Erscheinungsjahr
- 2020
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- : Since their discovery, neutrophil extracellular traps (NETs) have been implicated in a broad array of functions, both beneficial and detrimental to the host. Indeed, NETs have roles in infection, sepsis, wound healing, thrombotic disease, and cancer propagation, all of which are directly implicated in the care of surgical patients. Here we provide an updated review on the role of NETs in the perioperative period with specific emphasis on perioperative infections, wound healing, vascular complications, cancer propagation, as well as discussing ongoing, and future therapeutic targets. Surgeons will benefit from understanding the latest discoveries in neutrophil biology and how these novel functions affect the care of surgical patients. Furthermore, novel anti-NET therapies are being developed which may have profound effects on the care of surgical patients.
- Sprache
- Englisch
- Identifikatoren
- eISSN: 1528-1140DOI: 10.1097/SLA.0000000000003586Titel-ID: cdi_pubmed_primary_32675540
- Format
- –
- Schlagworte
- Animals, Biomarkers - metabolism, Extracellular Traps - metabolism, Female, Humans, Male, Mice, Neutrophils - metabolism, Perioperative Care - methods, Postoperative Complications - diagnosis, Postoperative Complications - metabolism, Risk Assessment, Sensitivity and Specificity, Surgical Procedures, Operative - adverse effects, Surgical Procedures, Operative - methods, Surgical Wound Infection - diagnosis, Surgical Wound Infection - metabolism, Wound Healing - physiology