Details

Autor(en) / Beteiligte

• Avula, Satya Kumar
• Rehman, Najeeb Ur
• Anwar, Muhammad U.
• Aalthani, Ghanim
• Csuk, Rene
• Al-Harrasi, Ahmed

Titel

Heterogeneous Pd/C-catalyzed, ligand free Suzuki-Miyaura coupling reaction furnishes new p-terphenyl derivatives

Ist Teil von

• Natural product research, 2022-01, Vol.36 (2), p.566-570

Ort / Verlag

England: Taylor & Francis

Erscheinungsjahr

2022

Quelle

Taylor & Francis

Beschreibungen/Notizen

• A series of new para-terphenyls derivatives have been efficiently synthesized by a ligand-free heterogeneous Pd/C-catalyzed two-fold Suzuki-Miyaura coupling reaction. Methyl 5-bromo-2-iodobenzoate was selected to react with a variety of different aryl boronic acids (2a-i). Nine new p-terphenyl derivatives (3a-i) were prepared and the structures were confirmed by several analytical techniques including infrared, spectroscopy, 1 H and 13 C NMR spectroscopy, mass spectrometry, and in the case of compound 3 b, by X-ray diffraction method. The new derivatives were obtained in very good yields (78-91%). This synthetic facile route is envisioned to improve the preparation of p-terphenyl-based natural products.