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The flaccid lung syndrome and alpha 1-protease inhibitor deficiency
Ist Teil von
Chest, 1988-04, Vol.93 (4), p.831
Ort / Verlag
United States: American College of Chest Physicians
Erscheinungsjahr
1988
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
We examined breathing mechanics and alpha 1PI deficiency in 1,850 unrelated male subjects with various lung complaints. The
loss in lung elasticity appeared to be significantly more pronounced in ZZ individuals as compared to MM, MS and also MZ individuals.
The MZ group did not differ significantly in this respect from MM individuals. This implies that the excess risk of developing
a flaccid lung (C greater than 1 kPa-1) due to the partial alpha 1-antitrypsin deficiency is negligible. PI MZ and PI ZZ frequencies
are significantly higher in the population with flaccid lung compared to control subjects. Furthermore, it was found that
the increase in residual volume in smokers is independent of the PI type.