Details

Autor(en) / Beteiligte

• Ford, Grayson J
• Kress, Nico
• Mattey, Ashley P
• Hepworth, Lorna J
• Baldwin, Christopher R
• Marshall, James R
• Seibt, Lisa S
• Huang, Min
• Birmingham, William R
• Turner, Nicholas J
• Flitsch, Sabine L

Titel

Synthesis of protected 3-aminopiperidine and 3-aminoazepane derivatives using enzyme cascades

Ist Teil von

• Chemical communications (Cambridge, England), 2020-07, Vol.56 (57), p.7949-7952

Ort / Verlag

England: Royal Society of Chemistry

Erscheinungsjahr

2020

Quelle

MEDLINE

Beschreibungen/Notizen

• Multi-enzyme cascades utilising variants of galactose oxidase and imine reductase led to the successful conversion of N -Cbz-protected l -ornithinol and l -lysinol to l -3- N -Cbz-aminopiperidine and l -3- N -Cbz-aminoazepane respectively, in up to 54% isolated yield. Streamlining the reactions into one-pot prevented potential racemisation of key labile intermediates and led to products with high enantiopurity. Synthesis of Cbz-protected 3-aminopiperidine and 3-aminoazepane using a multi-enzyme cascade consisting of galactose oxidase and imine reductase variants.