Details

Autor(en) / Beteiligte

• Rahmani, Parisa
• Abolhasani, Ruhollah
• Heidari, Ghobad
• Mohebbi, Ali
• Sayarifard, Fatemeh
• Rabbani, Ali
• Vafaei, Nahid
• Lotfi, Jabar

Titel

Determination of carnitine ester profile in the children with type 1 diabetes: a valuable step towards a better management

Ist Teil von

• Archives of physiology and biochemistry, 2022-09, Vol.128 (5), p.1209-1214

Ort / Verlag

England: Taylor & Francis

Erscheinungsjahr

2022

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Objective: This study is designed to investigate the levels of carnitine and acylcarnitines (ACs) in the children with diabetes type 1 compared to the healthy subjects. Methods: Forty-two type 1 diabetic children and healthy subjects were recruited in the study, respectively. In addition to FBS and Hb A1C, free carnitine and ACs in butyl-ester form in the fasting blood samples were assessed by isotope dilution mass spectrometry for all diabetics and controls using the tandem mass spectrometry system. Results: Diabetic patients had a higher level of C, C4, C6, C14, C18:2, and C18:2OH. Females had elevated C14:2 compared to the males. The C18:2 and C18:2OH levels were elevated as the Hb A1C level increased. The C18:2, C14OH were mostly increased in the prediabetic and diabetic patients, respectively. Conclusion: Increased ACs level indicates the increased acyl-CoA intermediates for the fatty acids and amino acids oxidation.