Bioscience, biotechnology, and biochemistry, 2020-08, Vol.84 (8), p.1546-1553
2020
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- Autor(en) / Beteiligte
- Titel
- An anti-inflammatory isoflavone from soybean inoculated with a marine fungus Aspergillus terreus C23-3
- Ist Teil von
- Bioscience, biotechnology, and biochemistry, 2020-08, Vol.84 (8), p.1546-1553
- Ort / Verlag
- England: Taylor & Francis
- Erscheinungsjahr
- 2020
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- A new isoflavone derivative compound 1 (psoralenone) was isolated from soybean inoculated with a marine fungus Aspergillus terreus C23-3, together with seven known compounds including isoflavones 2-6, butyrolactone I (7) and blumenol A (8). Their structures were elucidated by MS, NMR, and ECD. Psoralenone displayed moderate in vitro anti-inflammatory activity in the LPS-induced RAW264.7 cell model. Compound 2 (genistein) showed moderate acetylcholinesterase (AChE) inhibitory activity whereas compounds 2, 5 (biochanin A), 6 (psoralenol), and 7 exhibited potent larvicidal activity against brine shrimp. Compounds 3 (daidzein), 4 (4ʹ-hydroxy-6,7-dimethoxyisoflavone), and 5-7 showed broad-spectrum anti-microbial activity, and compound 7 also showed moderate 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity. An anti-inflammatory isoflavone from soybean fermented by a marine fungus Aspergillus terreus C23-3 An anti-inflammatory isoflavone from soybean fermented by a marine fungus Aspergillus terreus C23-3
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0916-8451eISSN: 1347-6947DOI: 10.1080/09168451.2020.1764838Titel-ID: cdi_pubmed_primary_32434451
- Format
- –
- Schlagworte
- 4-Butyrolactone - analogs & derivatives, 4-Butyrolactone - isolation & purification, 4-Butyrolactone - pharmacology, Acetylcholinesterase, Animals, Anti-Infective Agents - isolation & purification, Anti-Infective Agents - pharmacology, anti-inflammation, Anti-Inflammatory Agents - isolation & purification, Anti-Inflammatory Agents - pharmacology, Aspergillus - chemistry, Aspergillus - physiology, Aspergillus terreus, Cholinesterase Inhibitors - isolation & purification, Cholinesterase Inhibitors - pharmacology, Cyclohexanones - isolation & purification, Cyclohexanones - pharmacology, Free Radical Scavengers - isolation & purification, Free Radical Scavengers - pharmacology, Furocoumarins - isolation & purification, Furocoumarins - pharmacology, Genistein - isolation & purification, Genistein - pharmacology, Glycine max - chemistry, Glycine max - microbiology, Inflammation, isoflavone, Isoflavones - isolation & purification, Isoflavones - pharmacology, Lipopolysaccharides - antagonists & inhibitors, Lipopolysaccharides - pharmacology, marine fungus, Mice, RAW 264.7 Cells, Soybean