Nature methods, 2020-06, Vol.17 (6), p.609-613
2020
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Details
- Autor(en) / Beteiligte
- Titel
- Elasticizing tissues for reversible shape transformation and accelerated molecular labeling
- Ist Teil von
- Nature methods, 2020-06, Vol.17 (6), p.609-613
- Ort / Verlag
- United States
- Erscheinungsjahr
- 2020
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- We developed entangled link-augmented stretchable tissue-hydrogel (ELAST), a technology that transforms tissues into elastic hydrogels to enhance macromolecular accessibility and mechanical stability simultaneously. ELASTicized tissues are highly stretchable and compressible, which enables reversible shape transformation and faster delivery of probes into intact tissue specimens via mechanical thinning. This universal platform may facilitate rapid and scalable molecular phenotyping of large-scale biological systems, such as human organs.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1548-7091eISSN: 1548-7105DOI: 10.1038/s41592-020-0823-yTitel-ID: cdi_pubmed_primary_32424271
- Format
- –
- Schlagworte
- Acrylamide - chemistry, Animals, Biomechanical Phenomena, Biomimetic Materials - chemistry, Bioprinting, Cerebral Cortex - chemistry, Cross-Linking Reagents - chemistry, Elastic Modulus, Hippocampus - chemistry, Humans, Hydrogels - chemistry, Materials Testing, Mice, Staining and Labeling - methods, Stress, Mechanical, Tensile Strength, Tissue Engineering - methods