Details

Autor(en) / Beteiligte

• Markar, Sheraz R
• Zaninotto, Giovanni
• Castoro, Carlo
• Johar, Asif
• Lagergren, Pernilla
• Elliott, Jessie A
• Gisbertz, Suzanne S
• Mariette, Christophe
• Alfieri, Rita
• Huddy, Jeremy
• Sounderajah, Viknesh
• Pinto, Eleonora
• Scarpa, Marco
• Klevebro, Fredrik
• Sunde, Berit
• Murphy, Conor F
• Greene, Christine
• Ravi, Narayanasamy
• Piessen, Guillaume
• Brenkman, Hylke
• Ruurda, Jelle P
• Van Hillegersberg, Richard
• Lagarde, Sjoerd
• Wijnhoven, Bas
• Pera, Manuel
• Roig, José
• Castro, Sandra
• Matthijsen, Robert
• Findlay, John
• Antonowicz, Stefan
• Maynard, Nick
• McCormack, Orla
• Ariyarathenam, Arun
• Sanders, Grant
• Cheong, Edward
• Jaunoo, Shameen
• Allum, William
• Van Lanschot, Jan
• Nilsson, Magnus
• Reynolds, John V
• van Berge Henegouwen, Mark I
• Hanna, George B

Titel

Lasting Symptoms After Esophageal Resection (LASER): European Multicenter Cross-sectional Study

Ist Teil von

• Annals of surgery, 2022-02, Vol.275 (2), p.e392-e400

Ort / Verlag

United States

Erscheinungsjahr

2022

Quelle

MEDLINE

Beschreibungen/Notizen

• To identify the most prevalent symptoms and those with greatest impact upon health-related quality of life (HRQOL) among esophageal cancer survivors. Long-term symptom burden after esophagectomy, and associations with HRQOL, are poorly understood. Between 2010 and 2016, patients from 20 European Centers who underwent esophageal cancer surgery, and were disease-free at least 1 year postoperatively were asked to complete LASER, EORTC-QLQ-C30, and QLQ-OG25 questionnaires. Specific symptom questionnaire items that were associated with poor HRQOL as identified by EORTC QLQ-C30 and QLQ-OG25 were identified by multivariable regression analysis and combined to form a tool. A total of 876 of 1081 invited patients responded to the questionnaire, giving a response rate of 81%. Of these, 66.9% stated in the last 6 months they had symptoms associated with their esophagectomy. Ongoing weight loss was reported by 10.4% of patients, and only 13.8% returned to work with the same activities.Three LASER symptoms were correlated with poor HRQOL on multivariable analysis; pain on scars on chest (odds ratio (OR) 1.27; 95% CI 0.97-1.65), low mood (OR 1.42; 95% CI 1.15-1.77) and reduced energy or activity tolerance (OR 1.37; 95% CI 1.18-1.59). The areas under the curves for the development and validation datasets were 0.81 ± 0.02 and 0.82 ± 0.09 respectively. Two-thirds of patients experience significant symptoms more than 1 year after surgery. The 3 key symptoms associated with poor HRQOL identified in this study should be further validated, and could be used in clinical practice to identify patients who require increased support.