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Based on the new mission of public health set in the Healthy China strategy and the insufficient response to COVID-19, this article pointed out the problems of the current public health and preventive medicine system from the macro-system level, meso-organization level, and micro-individual level, including insufficient strategic planning, resource input, institutional coordination, talent training and team building. It was creatively proposed that a disease prevention and control bureau should be set up outside the health commission to implement the vertical management at four levels, from national level to province-level, including autonomous region, municipality directly under the central government, city-level and district/county-level. The disease prevention and control bureau should consist of a strategic research institute, a center for disease prevention and control (CDC), a human resources training base, and a scientific research institute, which could perform their own duties and rely on each other.